EXPOSURE TO ELEVATED GLUCOCORTICOID DURING DEVELOPMENT PRIMES ALTERED TRANSCRIPTIONAL RESPONSES TO ACUTE STRESS IN ADULTHOOD

Exposure to elevated glucocorticoid during development primes altered transcriptional responses to acute stress in adulthood

Summary: Early life stress (ELS) is a major risk factor for developing psychiatric disorders, with glucocorticoids (GCs) implicated in mediating its effects in shaping adult phenotypes.In this process, exposure to high levels of developmental GC (hdGC) is thought to induce molecular changes that prime differential adult responses.However, identitie

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Future Potential of Trans-Caspian Corridor: Review

Background: The Middle Corridor, a transport route from Asia to Europe that also facilitates major energy projects through the Caspian Sea and its surrounding countries, has gained even more attention after sofia barclay sexy the intensification of the conflict in Ukraine in 2022.Methods: On the basis of major scientific papers on the topic, foreig

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Immunotherapy-Induced Sarcoid-Like Reaction: A Shrewd Imitator

A 40-year-old male with a right-sided neck mass was diagnosed with metastatic melanoma.A repeat positron-emission tomography after treatment with combination immunotherapy demonstrated increased hypermetabolic activity in the right supraclavicular, hilar, and mediastinal regions.Immunotherapy was discontinued and a BRAF/MEK inhibitor combination wa

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Justification of the parameter that determines the ability of turbochargers of agricultural machinery engines to function

As a result of the analysis of statistics on the main failures of the turbocharger of tractor engines in agricultural production, it can be concluded that it is the condition of its bearing node, in the first place, determines the performance of the entire turbocharger.This ultimately affects the duration of the turbocharger rotor after the engine

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